HTR1B Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:8,000. WB: 1-3µg/ml.
Reactivity	Human, Mouse, Rat, Feline, Dog, Pig, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-SNEDFKQAFHK, from the C Terminus of the protein sequence according to NP_000854.1.
Isotype	IgG
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	47194 Da
Gene Name	5-hydroxytryptamine receptor 1B
Database Link	NP_000854 Entrez Gene 15551 MouseEntrez Gene 25075 RatEntrez Gene 403741 DogEntrez Gene 3351 Human UniProt ID P28222
Background	The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of 4 main groups, 5-HT-1, 5-HT-2, 5-HT-3, and 5-HT4, subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins. [supplied by OMIM]
Synonyms	5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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