INSIG1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	Western Blot: 2 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide representing an internal region of the human protein (between residues 1-100) according to Swiss-Prot# O15503.
Isotype	IgG
Formulation	PBS + 30% glycerol and 0.1% sodium azide
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	insulin induced gene 1
Database Link	NP_005533 Entrez Gene 3638 Human UniProt ID O15503
Background	Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms	CL-6; CL6
Reference Data
Protein Families	Druggable Genome, Transmembrane

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