p90 Autoantigen (KIAA1524) Mouse Monoclonal Antibody [Clone ID: 2G10]

Specifications

Product Data
Clone Name	2G10
Applications	FC, ICC/IF, IHC, WB
Recommend Dilution	Knockdown Validated, Western Blot: 1:1000-1:2000, Immunocytochemistry/ Immunofluorescence: 1:40, Flow Cytometry: 1 ug per million cells, Immunohistochemistry: 1:100 - 1:200, Immunohistochemistry-Paraffin
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A C-terminal portion of the human p90 protein.
Formulation	Tris-glycine, 150mM NaCl and 0.05% sodium azide
Concentration	lot specific
Purification	protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	KIAA1524
Database Link	NP_065941 Entrez Gene 57650 Human UniProt ID Q8TCG1
Background	Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Synonyms	CIP2A; p90
Reference Data
Protein Families	Druggable Genome

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