Caveolin 1 (CAV1) Mouse Monoclonal Antibody [Clone ID: 7C8]

Specifications

Product Data
Clone Name	7C8
Applications	FC, ICC/IF, IHC, Immunoblotting, IP, WB
Recommend Dilution	Immunohistochemistry: 1:100-1:300, Immunohistochemistry-Paraffin: 1:100-1:300, Western Blot: 1:1000-1:4000, Immunocytochemistry/ Immunofluorescence: 1:200, Immunohistochemistry-Frozen, Immunoblotting, Flow Cytometry: 1 ug per million cells, Immunoprecipitation: 1-2 ug / 500 ug of protein
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Glut 4 vesicles.
Isotype	IgG2b
Formulation	Tris-glycine and 150mM NaCl containing 0.05% sodium azide. and Sodium Azide
Purification	protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caveolin 1
Database Link	NP_001744 Entrez Gene 12389 MouseEntrez Gene 25404 RatEntrez Gene 857 Human UniProt ID Q03135
Background	Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo . Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
Synonyms	BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Focal adhesion, Viral myocarditis

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