HIF 2 alpha (EPAS1) Mouse Monoclonal Antibody [Clone ID: EP190B]

Specifications

Product Data
Clone Name	EP190B
Applications	ChIP, ELISA, FC, ICC/IF, IHC, IP, Simple Western, WB
Recommend Dilution	Chromatin Immunoprecipitation (ChIP), Gel Supershift Assay, Gel Super Shift Assays, Immunohistochemistry-Frozen, In vivo assay, Knockdown Validated, Western Blot: 1 - 2 ug/mL, Immunohistochemistry: 1:150 - 1:300, Immunohistochemistry-Paraffin: 1:150 - 1:300, Simple Western: 1:100, Flow Cytometry: 1:400, ELISA: 1:100-1:2000, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human HIF-2 alpha amino acids 535-631.
Formulation	PBS and 0.1% sodium azide
Purification	protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	endothelial PAS domain protein 1
Database Link	NP_001421 Entrez Gene 29452 RatEntrez Gene 2034 Human UniProt ID Q99814
Background	Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1 alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.
Synonyms	bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Pathways in cancer, Renal cell carcinoma

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