C1QA Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: 1/25-1/50.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Human C1q, purified from plasma.
Specificity	This antibody recognizes C1q, a sub-component of the C1 complement component.
Formulation	PBS, pH 7.2 containing 0.09% Sodium Azide as preservative Label: FITC State: Liquid purified IgG fraction Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	complement component 1, q subcomponent, A chain
Database Link	Entrez Gene 712 Human UniProt ID P02745
Background	C1q is a sub-component of the first complement component C1, which is formed by the interaction of C1q with the tetramer C1s-C1r-C1r-C1s. C1q is a member of a family of soluble collagen-like proteins and is composed of three basic subunits termed C1QA, C1QB and C1QC which asociate in the proportion 6 A-B subunits (52, 750 Da) and 3 C-C subunits (47,600 Da), to form whole C1q (459,300 Da). C1q binds to IgG and IgM immune complexes, this activates C1r and C1s, which are also bound to C1q and so initiates the classical pathway of complement activation.
Synonyms	Complement C1q, Complement 1q
Reference Data

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