NCR1 Mouse Monoclonal Antibody [Clone ID: n1D9]

Specifications

Product Data
Clone Name	n1D9
Applications	ELISA, FACS, FC, WB
Recommend Dilution	ELISA. Flow Cytometry. The antibody has been tested by immunofluorescent staining with flow cytometric analysis and by Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Note: this product is routinely tested on peripheral blood mononuclear cells (PBMCs) or natural killer (Nk) cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Nkp46 (22-255aa) purified from E. coli
Specificity	This antibody reacts to CD335.
Isotype	IgG1, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	natural cytotoxicity triggering receptor 1
Database Link	NP_004820 Entrez Gene 9437 Human UniProt ID O76036
Background	A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel Nk cell-specific molecule involved in human Nk cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in Nk cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.
Synonyms	NKp46 Extracellular Ig-like domain, NK-p46, NK cell-activating receptor, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen
Reference Data

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