NTAL (LAT2) Mouse Monoclonal Antibody [Clone ID: NAP-07]

Specifications

Product Data
Clone Name	NAP-07
Applications	FC
Recommend Dilution	Flow cytometry: Intracellular staining; recommended dilution: 1-5 μg/ml; positive tissue: RAJI human lymphoma cell line, RAMOS human lymphoma cell line.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant cytoplasmic domain (aa 91-243) of human NTAL
Specificity	This antibody reacts with Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B lymphocytes, NK cells and myeloid cells.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent Label: PE State: Liquid purified Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography
Concentration	lot specific
Conjugation	PE
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	linker for activation of T-cells family member 2
Database Link	Entrez Gene 56743 MouseEntrez Gene 7462 Human UniProt ID Q9GZY6
Background	NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Synonyms	LAB, NTAL, WBS15, WBSCR5, HSPC046
Reference Data
Protein Families	Transmembrane

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