CD42b / GPIbA Mouse Monoclonal Antibody [Clone ID: HIP1]

CAT#: SM3082P

CD42b / GPIbA mouse monoclonal antibody, clone HIP1, Purified



Need it in bulk or conjugated?
Get a free quote

SM3082P is a replacement of TA320340.

CNY 3,280.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name HIP1
Applications FC, FN, IHC
Recommend Dilution Flow Cytometry.
Immunohistochemistry on Frozen Sections.
Functional Application:
The antibody inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF) to platelets and ristocetin-induced platelet agglutination.
Reactivity Human, Primate
Host Mouse
Clonality Monoclonal
Immunogen Peripheral blood mononuclear cells of a patient suffering with CLL
Specificity CD42b antibody reacts with CD42b (GPIba), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIbb) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
Formulation Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative, approx. pH 7.4
State: Purified
State: Liquid purified Ig fraction (> 95% by SDS-PAGE).
Concentration lot specific
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name glycoprotein Ib platelet alpha subunit
Background CD42b (GPIba) composes together with GPIbb, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Synonyms Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...