CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: MEM-06]

Specifications

Product Data
Clone Name	MEM-06
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Leukocytes of patient suffering from LGL-type leukaemia
Specificity	This antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIba (heavy chain; 120 kDa) and GPIIbb (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide Label: FITC State: Liquid Ig fraction Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
Conjugation	FITC
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	integrin subunit alpha 2b
Database Link	Entrez Gene 3674 Human UniProt ID P08514
Background	CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, a and 23 kDa b, b) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Synonyms	Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb
Reference Data

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