CD321 / JAM1 Rat Monoclonal Antibody [Clone ID: H202-106]

Specifications

Product Data
Clone Name	H202-106
Applications	FC, IHC, IP
Recommend Dilution	Immunoprecipitation. Immunohistochemistry on Frozen Sections. Flow Cytometry: Use 10 µl of 1/100-1/200 diluted antibody to label 10e6 cells in 100 ul.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	MTE1/MTE2 stromal cell lines.
Specificity	Recognises murine CD321, which is also known as junctional adhesion molecule 1 (JAM-1).
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	F11 receptor
Database Link	Entrez Gene 16456 Mouse UniProt ID O88792
Background	CD321 is a 32-41kD glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. It is a multifunctional protein that is primarily expressed by platelets, endothelial and epithelial cells. The CD321 protein co-localises with tight junction molecules in both epithelial and endothelial cells and plays an important role in the regulation of junctional integrity and permeability. In addition, CD321 is a ligand for the integrin LFA-1 and is also involved in the transmigration of leucocytes.
Synonyms	JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1
Reference Data

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