DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: MR-1]

Specifications

Product Data
Clone Name	MR-1
Applications	FC, IF
Recommend Dilution	Immunofluorescence. Flow cytometry: 1/50 - 1/100. Use 10 µl of the suggested working dilution to label 10e6 cells in 100 µl.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Immature myeloid monocyte-derived dendritic cells (MDDCs)
Specificity	This antibody recognises DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN, CD209), a 45 kD C-type lectin that binds ICAM-3.
Isotype	IgG1
Formulation	PBS, pH 7.4, containing 0.09% sodium azide State: Purified State: Liquid IgG fraction
Concentration	lot specific
Purification	Protein G affinity chtromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD209 molecule
Database Link	Entrez Gene 30835 Human UniProt ID Q9NNX6
Background	CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro. CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's.
Synonyms	DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker
Note	Clone MR-1 is reported to partially block the functional activity of DC-SIGN (see ref. 2).
Reference Data

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