CD130 (IL6ST) Mouse Monoclonal Antibody [Clone ID: B-T2]

Specifications

Product Data
Clone Name	B-T2
Applications	ELISA, FC
Recommend Dilution	ELISA. Flow Cytometry: 0.2µg/106cells; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Natural soluble gp130 receptor. Spleen cells from immunised BALB/c (Iffa Credo) mice were fused with cells of the X63.Ag8.653 mouse myeloma cell line.
Specificity	This antibody specifically recognises soluble and membrane bound gp130 receptor. This antibody has been reported to block the activity of IL-6.
Formulation	PBS containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 6 signal transducer
Database Link	Entrez Gene 3572 Human UniProt ID P40189
Background	CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms	Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta
Reference Data

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