IGF2R Mouse Monoclonal Antibody [Clone ID: MEM-238]

Specifications

Product Data
Clone Name	MEM-238
Applications	FC, WB
Recommend Dilution	Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Reactivity	Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Vaccinia virus encoding CD222
Specificity	The antibody MEM-238 recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) solution containing 15mM sodium azide Label: PE State: Liquid purified Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation	PE
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	insulin like growth factor 2 receptor
Database Link	Entrez Gene 3482 Human UniProt ID P11717
Background	CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
Synonyms	CI-MPR, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, CI Man-6-P receptor, M6PR, Late Endosome Marker, M6P/IGF2R, MPR 300
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome

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