CD11c (ITGAX) Mouse Monoclonal Antibody [Clone ID: BU15]

Specifications

Product Data
Clone Name	BU15
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Dendritic cells of synovial fluid
Specificity	This antibody reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
Isotype	IgG1
Formulation	stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide Label: PerCP State: Liquid purified Ig fraction Label: Conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation	PerCP
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This products is photosensitive and should be protected from light.
Gene Name	integrin subunit alpha X
Database Link	Entrez Gene 3687 Human UniProt ID P20702
Background	CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
Synonyms	ITGAX, Integrin alpha-X, Leu M5
Reference Data

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