CD46 Mouse Monoclonal Antibody [Clone ID: MEM-258]

Specifications

Product Data
Clone Name	MEM-258
Applications	FC
Recommend Dilution	Indirect immunofluorescence analysis by Flow cytometry: 1:1000.
Reactivity	Human, Bovine
Host	Mouse
Clonality	Monoclonal
Immunogen	HPB-ALL human T cell line
Specificity	This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 Label: Biotin State: Liquid purified Ig fraction Label: Conjugated with -LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE!
Gene Name	CD46 molecule
Database Link	Entrez Gene 4179 Human UniProt ID P15529
Background	CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
Synonyms	TLX, MIC10
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Complement and coagulation cascades

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