Myelin Basic Protein (MBP) (129-138) Mouse Monoclonal Antibody [Clone ID: 1]

Specifications

Product Data
Clone Name	1
Applications	ELISA, IHC
Recommend Dilution	Immunohistochemistry on frozen sections: 1/10. ELISA: 1/200 - 1/1000.
Reactivity	Bovine, Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Bovine Myelin Basic Protein (MBP). Spleen cells from immunised NIH mice were fused with cells of the NSO mouse myeloma cell line.
Specificity	This antibody recognises myelin basic protein (MBP). Clone 1 is reactive with an epitope in the 129-138 region of the human MBP molecule. The numbering of MBP residues is that as described by Martenson.
Formulation	0.2M Tris/HCl pH7.4 containing 5-10% foetal calf serum and 0.09% Sodium Azide State: Supernatant State: Liquid Tissue Culture Supernatant
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	myelin basic protein
Database Link	Entrez Gene 4155 Human UniProt ID P02686
Background	The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
Synonyms	MBP
Reference Data

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