Factor I (CFI) Mouse Monoclonal Antibody [Clone ID: OX-21]

Specifications

Product Data
Clone Name	OX-21
Applications	ELISA, FC, IP, R, WB
Recommend Dilution	Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human complement Factor I Donor: Immunized FI cross DBA/2 x BALB/c mouse spleen cells Fusion Partner: NS-1 mouse myeloma
Specificity	Anti-human factor I (C3b inactivator) monoclonal antibody clone OX-21 recognizes human complement protein factor I. Factor I has two polypeptide chains, 56kD and 38kD. This antibody detects only the 56kD chain. This clone has been reported not to cross react with rat.
Isotype	IgG1
Formulation	PBS containing 0.02% sodium azide (NaN3) as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. Label: FITC State: Liquid purified Ig fraction Label: Fluorescein isothiocyanate isomer 1
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement factor I
Database Link	Entrez Gene 3426 Human UniProt ID P05156
Background	Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement protein breakdown products: Factor H, CR1 and MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage.
Synonyms	CFI, IF, KAF, AHUS3, C3BINA, C3b-INA
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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