IP10 (CXCL10) Mouse Monoclonal Antibody [Clone ID: 4D5]

Specifications

Product Data
Clone Name	4D5
Applications	ELISA, WB
Recommend Dilution	ELISA: 1-2 µg/ml. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human IP-10. Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3X63-AgP-653 myeloma cell line.
Specificity	This antibody recognises both natural and recombinant IP-10, also known as CXCL10.
Isotype	IgG1
Formulation	PBS, pH7.4 containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	C-X-C motif chemokine ligand 10
Database Link	Entrez Gene 3627 Human UniProt ID P02778
Background	Interferon-gamma-inducible 10 kD protein (IP-10), is a CXC chemokine with chemoattractant properties for CD4-positive T cells and inhibits early normal and leukemic hemopoietic progenitor proliferation. IP-10 is produced by a wide variety of cell types ranging from neutrophils and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV encephalitis, cutaneous T cell lymphoma, chronic hepatitis and acute anterior uveitis. Various observations strongly suggest a role for the CXC chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis.
Synonyms	C-X-C motif chemokine 10, Small-inducible cytokine B10, Gamma-IP10, INP10, SCYB10
Reference Data

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