CD42a (GP9) Mouse Monoclonal Antibody [Clone ID: GRP-P]

Specifications

Product Data
Clone Name	GRP-P
Applications	FC
Recommend Dilution	Flow Cytometry.
Reactivity	Canine, Human, Mink
Host	Mouse
Clonality	Monoclonal
Immunogen	Human red blood cells and platelets. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity	The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets. HLDA IV.; WS Code P 35.
Isotype	IgG1
Formulation	PBS, pH~7.4 Label: PE State: Lyophilized purified IgG fraction Stabilizer: 1% BSA, 5% Sucrose Preservative: 0.09% Sodium Azide Label: R. Phycoerythrin (RPE)
Reconstitution Method	Restore with 1 ml distilled water
Purification	Ion Exchange Chromatography
Conjugation	PE
Storage Condition	Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	glycoprotein IX platelet
Database Link	Entrez Gene 2815 Human UniProt ID P14770
Background	CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and Pselectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
Synonyms	Platelet glycoprotein IX, GP-IX, GP9
Reference Data

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