CD42a (GP9) Mouse Monoclonal Antibody [Clone ID: GRP-P]

Specifications

Product Data
Clone Name	GRP-P
Applications	FC
Recommend Dilution	Flow Cytometry.
Reactivity	Canine, Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human acute lymphoblastic leukemia cells
Specificity	The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets. HLDA IV.; WS Code P 35.
Isotype	IgG1
Formulation	PBS, pH~7.4 State: Purified State: Liquid purified IgG fraction from cell Culture Supernatant (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein-A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	glycoprotein IX platelet
Database Link	Entrez Gene 2815 Human UniProt ID P14770
Background	CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
Synonyms	Platelet glycoprotein IX, GP-IX, GP9
Reference Data

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