Tnfrsf4 Rat Monoclonal Antibody [Clone ID: OX-86]

Specifications

Product Data
Clone Name	OX-86
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: 1/10 - 1/50; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl. Immunohistochemistry on frozen sections.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	CHO cells transfected with murine OX40. Spleen cells from immunised AO rats were fused with cells of the mouse NS1 myeloma cell line.
Specificity	This antibody recognises OX40 (CD134), a cell surface antigen expressed only by activated T lymphocytes.
Isotype	IgG1
Formulation	PBS, pH7.4 containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily, member 4
Database Link	Entrez Gene 22163 Mouse UniProt ID P47741
Background	The OX40 receptor is also known as CD134, ACT35, and tumour necrosis factor receptor superfamily member 4. This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX40 receptor binds to the OX40 ligand to provide a co-stimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, imply that these interactions are important in the pathogenesis of some autoimmune diseases.
Synonyms	TNFRSF4, TXGP1L, ACT35 antigen, OX40L receptor
Reference Data

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