CD45 / LCA Rat Monoclonal Antibody [Clone ID: RA3-6B2]

Specifications

Product Data
Clone Name	RA3-6B2
Applications	FC, FN, IF, IHC, IP
Recommend Dilution	Flow cytometry. Immunoprecipitation. Immunohistochemistry on paraffin sections. Immunohistochemistry on frozen sections. Immnocytochemistry. Functional application: modulation of B cell responses.
Reactivity	Feline, Human, Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Abelson murine leukemia virus-induced pre-B tumor cells
Specificity	This antibody recognizes an epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells.T cells detected by this antibody are supposed to be in activated state.
Isotype	IgG2a
Formulation	Phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Low Endotoxin State: Liquid ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	protein tyrosine phosphatase, receptor type, C
Database Link	Entrez Gene 19264 Mouse UniProt ID P06800
Background	CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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