ALK Mouse Monoclonal Antibody [Clone ID: 5A4]

Specifications

Product Data
Clone Name	5A4
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen and Paraffin Sections (ABC method: 1/25-1/70). High temperature treatment of formalin-fixed tissue sections with 10mM citrate buffer, pH 6.0 must be performed prior to the immunostaining. Incubation Time: 60 minutes at room temperature. Positive Control: Anaplastic lymphoma.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of NPM-ALK transcript (419-520 aa).
Specificity	Recognizes ALK/p80. Cellular Localization: Cytoplasmic and/or nuclear.
Formulation	State: Supernatant State: Tissue Culture Supernatant
Purification	< 0.1 Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	anaplastic lymphoma receptor tyrosine kinase
Database Link	Entrez Gene 238 Human UniProt ID Q9UM73
Background	Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells, which express CD30 antigen and the epithelial membrane antigen (EMA). These tumor cells tend to occur in younger patients and may be associated with cutaneous and extranodal involvement. Large cell lymphoma account for approximately 25 % of all non-Hodgkin's lymphomas in children and young adults.
Synonyms	ALK tyrosine kinase receptor
Reference Data

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