VEGF Receptor 2 (KDR) Mouse Monoclonal Antibody [Clone ID: KDREWC]

Specifications

Product Data
Clone Name	KDREWC
Applications	ELISA, FC, WB
Recommend Dilution	ELISA (1-10 µg/ml) FACS analysis and Cell Sorting (2-20 µg/ml).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human soluble extracellular KDR protein (D7) (110 kDa)
Specificity	The monoclonal antibody will detect native Human VEGFR-2/KDR in ELISA experiments and on the surface of different Human cell types.
Isotype	IgG1
Formulation	PBS Label: Biotin State: Purified State: Lyophilized purified IgG fraction from Cell Culture Supernatant Stabilizer: 50xBSA Preservative: 0.02% Sodium Azide
Reconstitution Method	Restore in distilled sterile water to 0.1-1.0 mg/ml
Purification	Protein G Chromatography
Conjugation	Biotin
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	kinase insert domain receptor
Database Link	Entrez Gene 3791 Human UniProt ID P35968
Background	Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
Synonyms	VEGFR2, FLK1, KDR, VEGF Receptor 2
Reference Data

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