IL16 Mouse Monoclonal Antibody [Clone ID: 323]

Specifications

Product Data
Clone Name	323
Applications	ELISA
Recommend Dilution	ELISA: In combination with capture antibody Clone 398 (Cat.-No DM1026), this HRP conjugated antibody can be used as a tracer antibody for Human IL-16 detection.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant Human IL-16
Specificity	This antibody reacts with natural and recombinant IL-16. No cross-reactivity with Human Serum Albumin, Bovine Serum Albumin and other cytokines or growth factors tested such as IL-1beta, TGF-beta1, TNF-alpha, IL-8, IL-7, MCP-1, EGF, bFGF, GM-CSF.
Isotype	IgG2a
Formulation	0.01M PBS, pH 7.0 ± 0.1 in 50% Glycerol and 0.01% Thimerosal as a bacteriostat Label: HRP State: Liquid purified IgG fraction Label: Horseradish Peroxidase
Purification	Affinity Chromatography on Protein G
Conjugation	HRP
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	interleukin 16
Database Link	Entrez Gene 3603 Human UniProt ID Q14005
Background	IL16 is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. In addition to inducing chemotaxis, IL16 upregulates the IL2 receptor and upregulates HLADR expression. It also inhibits T cell receptor (TCR)/CD3 dependent activation, and suppresses HIV1 replication in vitro. Sources of IL16 include epithelial cells, mast cells, T lymphocytes (CD4+ and CD8+), macrophages, synovial fibroblasts, and eosinophils.
Synonyms	IL-16, LCF
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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