Cd207 Rat Monoclonal Antibody [Clone ID: 923B7]

Specifications

Product Data
Clone Name	923B7
Applications	IF
Recommend Dilution	DDX0373P-50 / DDX0373P-100 Purified: IHC, Flow cytometry. DDX0373A488-50 / DDX0373A488-100 Alexa-fluor®488: IF surface Flow cytometry. DDX0373A546-50 / DDX0373A546-100 Alexa-fluor®546: IF. DDX0373A647-50 / DDX0373A647-100 Alexa-fluor®647: Flow cytometry. DDX0373B-50 / DDX0373B-100 Biotin: Flow cytometry. Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before using.
Reactivity	Human, Mouse, Rat
Host	Rat
Clonality	Monoclonal
Immunogen	Human Langerin-transfected eukaryotic cells.
Specificity	Human Langerin (extracellular epitope). Species cross-reactivity: Rat, Mouse.
Isotype	IgG2a
Formulation	Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol. Label: Alexa Fluor 546
Concentration	lot specific
Purification	Hyper-D ion exchange chromatography
Conjugation	Alexa Fluor 546
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	CD207 antigen
Database Link	Entrez Gene 246278 Mouse UniProt ID Q8VBX4
Background	Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck’s granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 2002 J Immunol, 168 : 782-792) (Douillard P et al, 2005 J Invest Dermatol, 125: 983–994).
Synonyms	CLEC4K, Dendritic Cell Marker
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.