Cd8a Rat Monoclonal Antibody [Clone ID: 53.6.72(lyt2)]

Specifications

Product Data
Clone Name	53.6.72(lyt2)
Applications	FC
Recommend Dilution	Flow Cytometry: This monoclonal antibody may be used between 1-10 μg/ml.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	thymic and spleen mouse cells
Specificity	Mouse CD8α (Lyt-2).
Isotype	IgG2a
Formulation	State: Purified State: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles.
Gene Name	CD8 antigen, alpha chain
Database Link	Entrez Gene 12525 Mouse UniProt ID P01731
Background	CD8 exists in two forms: a CD8 heterodimer composed of a α chain and a ß chain; and a homodimer of two α chains (CD8α = Lyt2, Ly2, OX8). The heterodimer is found on essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC-Class I-restricted CD8+ T cells. CD8 is required for the development of cytotoxic T cells. (Ledbetter JA et al, 1979, Nat. Rev. Immunol., 47, 63: 425-30)
Synonyms	CD8 alpha chain, CD8A, MAL
Reference Data

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