RALBP1 Mouse Monoclonal Antibody [Clone ID: OTI6E8]

Specifications

Product Data
Clone Name	OTI6E8
Applications	IF, IHC, IP, WB
Recommend Dilution	WB 1:2000, IHC 1:50, IF 1:100, IP: 4ug/mL
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human RALBP1 (NP_006779) produced in HEK293T cell.
Isotype	IgG1
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	76.0 kDa
Gene Name	ralA binding protein 1
Database Link	NP_006779 Entrez Gene 19765 MouseEntrez Gene 84014 RatEntrez Gene 10928 Human UniProt ID Q15311
Background	Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin
Synonyms	RIP1; RLIP1; RLIP76
Reference Data
Protein Pathways	Pancreatic cancer, Pathways in cancer

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