XRCC1 Mouse Monoclonal Antibody [Clone ID: OTI3C3]

Specifications

Product Data
Clone Name	OTI3C3
Applications	IF, WB
Recommend Dilution	WB 1:2000, IF 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human XRCC1 (NP_006288) produced in HEK293T cell.
Isotype	IgG1
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	69.5 kDa
Gene Name	X-ray repair cross complementing 1
Database Link	NP_006288 Entrez Gene 22594 MouseEntrez Gene 84495 RatEntrez Gene 7515 Human UniProt ID P18887
Background	The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Synonyms	RCC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Base excision repair

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