Cytokeratin 15 (KRT15) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	Immunofluorescence Microscopy on Frozen Sections. Immunohistochemistry on frozen sections: 1:200-1:500 Immunohistochemistry on paraffin sections: 1:200-1:500 (protease treatment and/or microwave treatment recommended) Positive control: sweat glands of human skin (e.g. foot sole).
Reactivity	Human, Mouse
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Synthetic peptide of Human Keratin K15 (formerly also designated cytokeratin 15), coupled to KLH.
Specificity	MW 50,000 (pI 4.9) intermediate filament polypeptide, keratin K15, detected by Immunohistochemistry in basal cells of stratified epithelia (including epidermis, tongue, esophagus, exocervix) and complex stratified epithelia (e.g. bronchial epithelium), in luminal epithelia of mammary, salivary and sweat gland. In the hair follicle, staining was restricted to the basal cell layer of the outer root sheath. Completely non-reactive were cells of liver, colon.
Formulation	State: Serum State: Liquid Serum Preservative: 0.09% Sodium Azide Stabilizer: 0,5% BSA
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	keratin 15
Database Link	Entrez Gene 3866 Human UniProt ID P19012
Background	Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.
Synonyms	Cytokeratin-15, CK-15, K15, Keratin-15, Keratin 15, KRTB, KRT15
Reference Data

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