SQSTM1 (C-term) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blotting: 1/1000-1/2000 (ECL). Immunohistochemistry on Frozen Sections: 1/100-1/600. Immunohistochemistry on Paraffin Embedded Sections: 1/100-1/600 (microwave pretreatment improves staining). Incubation time: 1h at RT, extended with paraffin material.
Reactivity	Human, Mouse, Rat
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	C-terminal domain (20 amino acids: C-NYD IGA ALD TIQ YSK HPP PL) of Human p62 protein, coupled to KLH.
Specificity	This antibody reacts with Human 62 kD (p62) protein, present in intracytoplasmic inclusions (e.g. hyaline bodies) of hepatocellular carcinoma. p62 protein (also described as ubiqutin-binding protein; sequestosome 1, SQSTM1) has been found in many tissues and cells, including lymphoid cells, serving probably a common cellular signal transduction mechanism (e.g. ubiquitin-associated degradation and autophagy).  The antiserum stains also neurofibrillary tangles in the brain of patients suffering from Alzheimer's disease.
Formulation	State: Serum State: Liquid Stabilized Antiserum Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	sequestosome 1
Database Link	Entrez Gene 18412 MouseEntrez Gene 113894 RatEntrez Gene 8878 Human UniProt ID Q13501
Synonyms	Sequestosome-1, EBIAP, ORCA, OSIL, p60, p62
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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