Gbgt1 (Forssman antigen) Rat Monoclonal Antibody [Clone ID: FOM-1]

Specifications

Product Data
Clone Name	FOM-1
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: 0.5 μg/ml (1/1000). Immunohistochemistry on Paraffin Sections: 5 μg/ml (1/100). Pretreatment not necessary. Suggested Positive Control: Mouse spleen.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Specificity	The Monoclonal antibody FOM-1 detects the Forssman antigen. The FOM-1 antigen is a glycosphingolipid (FO GSL) differentiation antigen. Antigen Distribution: In tissue sections the antigen is found on macrophages in the red pulp of the spleen and the medulla of inguinal and axial lymph nodes. It's negative on monocytes and granulocytes. Reticular cells in T-cell areas of spleen and lymph nodes also stain positively. In response to inflammatory stimuli, a subpopulation of positive macrophages appear in the peritoneal cavity. Other macrophages in lymphoid and non lymphoid organs (e.g. alveolar macrophages and Kupffer cells) are negative. These results indicate that infiltrating macrophages carry the antigen.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	> 0.5 mg/ml
Purification	Partially purified by Dialysis and Gel Filtration
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Database Link	Entrez Gene 227671 Mouse UniProt ID Q8VI38
Background	The Forssman antigen was named after the Swedish pathologist John F. Forssman and later identified as the GalNAcα(1-3)GalNAcβ(1-R) disaccharide group. Forssman specificity was described in many animal species, plants and bacteria. In the mouse, Forssman antigen is a developmental and differentiation antigen. Expression of Forssman antigen in macrophages can be modulated by cytokines.
Synonyms	A3GALNT; FS; MGC44848; UDP-GalNAc; UNQ2513
Reference Data

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