Epstein Barr Virus / EBV Early Antigen-D Mouse Monoclonal Antibody [Clone ID: 261]

Specifications

Product Data
Clone Name	261
Applications	IF, WB
Recommend Dilution	Suitable for use in IFA, Western blot, and Immunohistochemistry (weak, antigen retrieval required).
Reactivity	Epstein Barr Virus
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant EB early antigen-diffuse.
Specificity	This antibody is specific for the "Early antigen-diffuse" (EA-D) 50-52 kD of EBV.
Isotype	IgG2
Formulation	0.01M PBS, pH 7.2 containing 0.09% Sodium Azide as preservative and no stabilizers. State: Purified State: Liquid purified Ig fraction (> 90% pure).
Concentration	lot specific
Purification	Protein A Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	EBV is a human herpesvirus, which is associated with conditions such as Hodgkins disease and Burkitts Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
Synonyms	HHV4, HHV-4
Reference Data

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