TSH beta (TSHB) Mouse Monoclonal Antibody [Clone ID: 057-11003]

Specifications

Product Data
Clone Name	057-11003
Applications	ELISA
Recommend Dilution	ELISA (capture).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TSH purified from human pituitary gland.
Specificity	Specific to intact TSH. Reacts with TSH through the alpha subunit/hinge region. Does not react with free beta subunit. Has limited reactivity to free alpha subunit. Cross-reactivity: TSH 100%, hCG 0.0%, LH 0.0%, FSH 0.0%.
Isotype	IgG1
Formulation	10mM Phosphate pH 7.4, 150 mM Sodium Chloride and containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction (> 90% pure by SDS-PAGE).
Concentration	lot specific
Purification	Affinity Chromatography on Protein A.
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thyroid stimulating hormone beta
Database Link	Entrez Gene 7252 Human UniProt ID P01222
Background	Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
Synonyms	Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH, TSHB, TSH beta
Reference Data

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