Plasma Kallikrein 1B (KLKB1) Mouse Monoclonal Antibody [Clone ID: 901]

Specifications

Product Data
Clone Name	901
Applications	ELISA, FN, WB
Recommend Dilution	Suitable for use in ELISA and Western blot. Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasma samples.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Human prekallikrein.
Specificity	Recognizes two variants of Prekallikrein and its activation products Kallikrein (88 kDa and 85 kDa), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and Antithrombin III, and 45 kDa prekallikrein/kallikrein fragment(s). Recognizes Prekallikrein and its activation products in Human, Chimpanzee, Rhesus, and Baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in Human and Rhesus plasmas by approximately 60-80% and 55%, respectively. Does not cross-react with tissue Kallikrein
Isotype	IgG1
Formulation	PBS, pH 7.4 without preservatives. State: Azide Free State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	kallikrein B1
Database Link	Entrez Gene 3818 Human UniProt ID P03952
Background	Plasma Kallikrein 1B is a serine proteinase of the S1 family It is secreted by the liver, kidney, adrenal gland and placenta. The zymogen is referred to as prekallikrein (PK) and is activated by Factor XIIa to an active two chain form, plasma kallikrein. In Fletcher syndrome plasma kallikrein is deficient, resulting in a prolonged partial thromboplastin time (PT).
Synonyms	Plasma kallikrein, Fletcher factor
Reference Data

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