CD32B (FCGR2B) pTyr292 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:500~1:1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide sequence around phosphorylation site of tyrosine 292 (I-T-Y(p)-S-L) derived from Human CD32 (KLH-conjugated)
Specificity	The antibody detects endogenous levels of CD32 only when phosphorylated at tyrosine 292.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography using epitope-specific peptide
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	32 kDa
Gene Name	Fc fragment of IgG receptor IIb
Database Link	Entrez Gene 2213 Human UniProt ID P31994
Background	Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Synonyms	FCGR2B, FCG2, IGFR2, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b
Reference Data

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