Tyr Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/2000. Immunohistochemistry: 1/50-1/500.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from C-terminal domain of TYRO protein.
Specificity	Reacts with Mouse 60 kDa protein. This antibody cross reacts with Human and other species.
Formulation	State: Serum State: Lyophilized powder Preservative: None
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer Avoid repeated freezing and thawing.
Gene Name	tyrosinase
Database Link	Entrez Gene 22173 Mouse UniProt ID P11344
Background	Tyrosinase is a copper containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. It is thought to catalyze the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. A mutant allele of TYR is a common cause of autosomal recessive ocular albinism, also known as tyrosinase negative oculocutaneous albinism. This is an autosomal recessive disorder characterized by absence of pigment in hair, skin and eyes.
Synonyms	LB24-AB; OCA1A; OCAIA; SHEP3; SK29-AB; tyrosinase
Reference Data

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