TRAF4 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:1;000. Western blot: 1:100~500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 426-455 amino acids from the C-terminal region of human TRAF4
Specificity	This antibody detects TRAF4 / RNF83 (C-term).
Formulation	PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid ig fraction
Concentration	lot specific
Purification	Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	TNF receptor associated factor 4
Database Link	Entrez Gene 9618 Human UniProt ID Q9BUZ4
Background	This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
Synonyms	TNF receptor-associated factor 4, CART1, MLN62
Note	Molecular Weight: 53543 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Pathways in cancer, Small cell lung cancer

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