STING (TMEM173) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	ELISA: 1:1;000. Western blot: 1:100~500. Flow cytometry: 1:10~50.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human TMEM173.
Specificity	This antibody detects TMEM173 / STING (C-term).
Isotype	Ig
Formulation	PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	transmembrane protein 173
Database Link	Entrez Gene 72512 MouseEntrez Gene 340061 Human UniProt ID Q86WV6
Background	Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Synonyms	Transmembrane protein 173, MITA
Note	Molecular Weight: 42193 Da
Reference Data
Protein Pathways	Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway

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