SPG7 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/10-1/50. Western blot: ~1/1000. Enzyme immunoassay: 1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated corresponding to the central region (between 115-141aa) of Human Paraplegin / SPG7
Specificity	This antibody recognizes Human Paraplegin / SPG7. Other species not tested.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	88235 Da (calculated)
Gene Name	SPG7, paraplegin matrix AAA peptidase subunit
Database Link	Entrez Gene 6687 Human UniProt ID Q9UQ90
Background	The SPG7 gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7.
Synonyms	Spastic paraplegia 7 protein, CAR, CMAR, PGN
Reference Data
Protein Families	Protease, Transmembrane

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