Neuroserpin (SERPINI1) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunofluorescence: 1/10-1/50. Immunohistochemistry: 1/50-1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of Human SERPINI1.
Specificity	Recognizes SERPINI1 (N-term).
Isotype	Ig
Formulation	PBS with 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column followed by peptide Affinity purification
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	serpin family I member 1
Database Link	Entrez Gene 5274 Human UniProt ID Q99574
Background	This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms	Serpin I1, PI12, PI-12
Note	Molecular Weight: 46427 Da
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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