COX2 (PTGS2) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.  Immunofluorescence: 1/10-1/50.  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 370-399 amino acids from the Central region of Human Cyclooxygenase 2.
Specificity	This antibody recognizes Human Cyclooxygenase 2 (Center).
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	prostaglandin-endoperoxide synthase 2
Database Link	Entrez Gene 5743 Human UniProt ID P35354
Background	Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis
Synonyms	Cyclooxygenase-2, PTGS2, COX2, PHS II, PGH synthase 2, PGHS-2, PGHS2
Note	Molecular Weight: 68996 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Pathways in cancer, Small cell lung cancer, VEGF signaling pathway

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