G protein coupled receptor 30 (GPER1) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100 - 1/500.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 345-375 amino acids from the C-terminal region of human GPER
Specificity	This antibody reacts to GPER.
Isotype	Ig
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide
Concentration	lot specific
Purification	Affinity chromatography on Protein A followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	42248 Da
Gene Name	G protein-coupled estrogen receptor 1
Database Link	Entrez Gene 76854 MouseEntrez Gene 2852 Human UniProt ID Q99527
Background	This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq].
Synonyms	G-protein coupled receptor 30, Chemoattractant receptor-like 2, GPCR-BR, CEPR, CMKRL2, DRY12, FEG1, LYGPR
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane

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