FLIP (CFLAR) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/50 - 1/100. Immunohistochemistry on paraffin sections:  1/50 - 1/100. Flow Cytometry: 1/10 - 1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 152~182 amino acids from the Center region of human CFLAR
Specificity	This antibody reacts to CFLAR.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	55344 Da
Gene Name	CASP8 and FADD like apoptosis regulator
Database Link	Entrez Gene 8837 Human UniProt ID O15519
Background	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. It lacks enzymatic (caspase) activity.
Synonyms	c-FLIP, CLARP, MRIT, CASH, FLAME-1, CASP8AP1, Usurpin
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Apoptosis

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