ARHGEF6 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/1,000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 614-641 amino acids from the C-terminal region of human ARHGEF6
Specificity	This antibody reacts to ARHGEF6.
Isotype	Ig
Formulation	PBS containing 0.09% (W/V) sodium azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Rac/Cdc42 guanine nucleotide exchange factor 6
Database Link	Entrez Gene 9459 Human UniProt ID Q15052
Background	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
Synonyms	COOL2, KIAA0006, PIXA, Alpha-Pix, COOL-2
Note	Molecular Weight: Isoform2 71kd. 87499 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Pancreatic cancer, Regulation of actin cytoskeleton

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