SLC10A2 (C-term) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	Peptide ELISA: 1/16000 (Detection limit). Western blot: Preliminary experiments gave an approx. 60kDa band in Human Kidney lysates after 0.1 µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 37.7kDa according to NP_000443.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.  Immunohistochemistry on Paraffin Sections: 3-6 μg/ml. In paraffin embedded Human Small Intestine shows staining of cells in the laminia propria between the intestinal vili.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide with sequence from the C-Terminus of Human SLC10A2 (NP_000443.1).
Specificity	This antibody detects SLC10A2 at C-term.
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 10 member 2
Database Link	Entrez Gene 6555 Human UniProt ID Q12908
Background	This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq]
Synonyms	ASBT, ISBT, NTCP2, IBAT
Reference Data

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