Caveolin 1 (CAV1) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide from C-terminal domain of human caveolin-1
Specificity	This antibody reacts to the C-term of Caveolin-1 (CAV1).
Formulation	10 mM PBS, pH 7.4 containing BSA as stabilizer and 0,09% sodium azide as preservative State: Purified State: Liquid purfied Ig fraction
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	caveolin 1
Database Link	Entrez Gene 857 Human UniProt ID Q03135
Background	Caveolae (also known as plasmalemmal vesicles) are 50-100 nm flask- shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL( across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components of caveolae. Caveolin 1 (CAV1) is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 functions as a membrane adaptor to link integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 may also be a tumor suppressor gene and a negative regulator of the Ras-p42/44 MAP kinase cascade.
Synonyms	CAV1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Focal adhesion, Viral myocarditis

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