KCNK2 (4-14) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA: The antibody (1:500,000 diluted) can detect the TREK-1 peptide coated on ELISA plate at 100ng/well. Western blot: Dilute approx. 1:3,000 to detect the 47kDa TREK-1 in Jurkat cell extract.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from the amino sequence 4-14 of human TREK-1, conjugated with KLH
Specificity	This antibody reacts with the 47kDa TREK-1 in Jurkat cell extract.
Formulation	0.01M PBS, pH 7.4 State: Azide Free State: Lyophilized Ig fraction
Reconstitution Method	Restore with double distilled water to adjust the final concentration to 1.00 mg/ml.
Purification	Protein G affinity
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	potassium two pore domain channel subfamily K member 2
Database Link	Entrez Gene 3776 Human UniProt ID O95069
Background	TWIK-related potassium channel 1(TREK-1), also known as K2P2.1, is a two pore domain gated potassium channel that is involved with pain reception. TREK-1 is highly expressed in small sensory neurons and is extensively colocalized with TRPV1. TREK-1 is sensitive to noxious stimuli including extracellular pH, temperature, mechanical force, osmotic pressure and other stimuli. TREK-1 is one of the targets for pain mediator and anaesthesia drug.
Synonyms	KCNK2, TREK, TREK1, Potassium channel subfamily K member 2, Two pore potassium channel TPKC1
Reference Data

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