ACTN3 (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/20000. Immunohistochemistry on Paraffin Sections: 1/100. Western Blot: 1/500 - 1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ACTN3 antibody was raised against synthetic peptide - KLH conjugated
Specificity	This antibody reacts to the N-term of Alpha-actinin 3, Skeletal Muscle Isoform (ACTN3).
Isotype	IgG
Formulation	PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM sodium chloride, 0.02% sodium azide as preservative and 50% glycerol as stabilizer State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	actinin alpha 3 (gene/pseudogene)
Database Link	Entrez Gene 11474 MouseEntrez Gene 171009 RatEntrez Gene 89 Human UniProt ID Q08043
Background	Alpha-actinin is an actin-binding protein with multiple roles in different cell types. ACTN3 expression is limited to skeletal muscle. It is localized to the Z-disc and analogous dense bodies, where it helps to anchor the myofibrillar actin filaments.
Synonyms	Alpha actinin skeletal muscle isoform 3
Reference Data
Protein Pathways	Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Systemic lupus erythematosus, Tight junction

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